Effect of probiotics on the development of dimethylhydrazine-induced preneoplastic lesions in the mice colon
Acta cir. bras
; 28(5): 367-372, May 2013. ilus, tab
Article
em En
| LILACS
| ID: lil-674157
Biblioteca responsável:
BR1.1
ABSTRACT
PURPOSE:
To determine the effect of probiotics on the development of chemically induced (1, 2-dimethylhydrazine) colonic preneoplastic lesions, in mice.METHODS:
The animals were divided into five groups. The control group was injected with carcinogen alone and the other groups also received probiotics (1- Lactobacillus delbrueckii UFV-H2b20; 2- Bifidobacterium animalis var. lactis Bb12; 3- L. delbrueckii UFV-H2b20 plus B. animalis var. lactis Bb12; and 4- Saccharomyces boulardii) administered orally in drinking water throughout fourteen weeks.RESULTS:
Consumption of lactobacilli and bifidobacteria alone resulted in a significant reduction of the total number of aberrant crypt foci (55.7% and 45.1%, respectively). Significant reduction in the number of these small foci (<3 aberrant crypts) was only observed in the group treated with lactobacilli (52.2%) in comparison to control group. The number of larger foci (>3 aberrant crypts) crypts had no significant reduction.CONCLUSION:
L. delbrueckii UFV-H2b20 and B. animalis var. lactis Bb12 administered alone protect colonic preneoplastic lesions in mice, while the combined treatment of these bacteria and the administration of S.boulardii were not effective in reducing such colonic lesions.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Lesões Pré-Cancerosas
/
Neoplasias do Colo
/
Probióticos
/
Focos de Criptas Aberrantes
Limite:
Animals
Idioma:
En
Revista:
Acta cir. bras
Ano de publicação:
2013
Tipo de documento:
Article