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Morphologic features frommdxmice spleens, used for duchenne muscular dystrophy studies
Santos, A. C; Oliveira, D. M; Bertassoli, B M; Viana, D. C; Vasconcelos, B. G; Assis Neto, A. C.
Afiliação
  • Santos, A. C; São Paulo University. Faculty of Veterinary Medicine and Animal Science. Department of Wild and Domestic Animals. BR
  • Oliveira, D. M; São Paulo University. Faculty of Veterinary Medicine and Animal Science. Department of Wild and Domestic Animals. BR
  • Bertassoli, B M; São Paulo University. Faculty of Veterinary Medicine and Animal Science. Department of Wild and Domestic Animals. BR
  • Viana, D. C; s.af
  • Vasconcelos, B. G; s.af
  • Assis Neto, A. C; São Paulo University. Faculty of Veterinary Medicine and Animal Science. Department of Wild and Domestic Animals. BR
Braz. j. morphol. sci ; 30(1): 21-27, 2013. ilus, tab
Artigo em Inglês | LILACS | ID: lil-699326
Biblioteca responsável: BR734.1
ABSTRACT
The mdx mice model is widely used for Duchenne muscular dystrophy (DMD) studies, which is present in a high percentage from newborns human males. Therefore, the aim of this study was to evaluate possible morphological changes from spleens in these mice and to compare with normal mice (Mus musculus) in contribution to DMD understanding and its consequences on immune system by affected individuals. The study was performed by light and scanning electron microscopy (SEM) techniques beyond immunohistochemistry. Was found microscopically an increased number of lymph nodes and decreased in red pulp region by mdx, beyond a larger VEGF-C (vascular endothelial growth factor C) expression stimulates lymphangiogenesis in red pulp region from spleen. These findings suggest a spleen adaptation in order to supply immunological demand due upper respiratory infection, which are common in individuals affected by Duchenne muscular dystrophy.
Assuntos

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Infecções Respiratórias / Linfócitos / Distrofia Muscular de Duchenne / Fator A de Crescimento do Endotélio Vascular / Sistema Imunitário Limite: Animais Idioma: Inglês Revista: Braz. j. morphol. sci Ano de publicação: 2013 Tipo de documento: Artigo

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Infecções Respiratórias / Linfócitos / Distrofia Muscular de Duchenne / Fator A de Crescimento do Endotélio Vascular / Sistema Imunitário Limite: Animais Idioma: Inglês Revista: Braz. j. morphol. sci Ano de publicação: 2013 Tipo de documento: Artigo