Emerging Plasmodium vivax resistance to chloroquine in South America: an overview
Mem. Inst. Oswaldo Cruz
; 109(5): 534-539, 19/08/2014. graf
Article
em En
| LILACS
| ID: lil-720432
Biblioteca responsável:
BR1.1
ABSTRACT
The global emergence of Plasmodium vivax strains resistant to chloroquine (CQ) since the late 1980s is complicating the current international efforts for malaria control and elimination. Furthermore, CQ-resistant vivax malaria has already reached an alarming prevalence in Indonesia, East Timor and Papua New Guinea. More recently, in vivo studies have documented CQ-resistant P. vivax infections in Guyana, Peru and Brazil. Here, we summarise the available data on CQ resistance across P. vivax-endemic areas of Latin America by combining published in vivo and in vitro studies. We also review the current knowledge regarding the molecular mechanisms of CQ resistance in P. vivax and the prospects for developing and standardising reliable molecular markers of drug resistance. Finally, we discuss how the Worldwide Antimalarial Resistance Network, an international collaborative effort involving malaria experts from all continents, might contribute to the current regional efforts to map CQ-resistant vivax malaria in South America.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
LILACS
Assunto principal:
Plasmodium vivax
/
Resistência a Medicamentos
/
Cloroquina
/
Malária Vivax
/
Antimaláricos
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
America do sul
/
Bolivia
/
Brasil
/
Caribe ingles
/
Colombia
/
Guyana
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Ano de publicação:
2014
Tipo de documento:
Article