Oleanolic acid and ursolic acid inhibit peptidoglycan biosynthesis in Streptococcus mutans UA159

Park, Soon-Nang; Ahn, Sug-Joon; Kook, Joong-Ki

Park, Soon-Nang; Ahn, Sug-Joon; Kook, Joong-Ki.

Afiliação

Park, Soon-Nang; Chosun University. School of Dentistry. Korean Collection for Oral Microbiology and Department of Oral Biochemistry. Gwangju. KR
Ahn, Sug-Joon; Chosun University. School of Dentistry. Korean Collection for Oral Microbiology and Department of Oral Biochemistry. Gwangju. KR
Kook, Joong-Ki; Chosun University. School of Dentistry. Korean Collection for Oral Microbiology and Department of Oral Biochemistry. Gwangju. KR

Braz. j. microbiol ; 46(2): 613-617, Apr-Jun/2015. tab, graf

Article em En | LILACS | ID: lil-749716

Biblioteca responsável: BR1.1

ABSTRACT

ABSTRACT

In this study, we revealed that OA and UA significantly inhibited the expression of most genes related to peptidoglycan biosynthesis in S. mutans UA159. To the best of our knowledge, this is the first report to introduce the antimicrobial mechanism of OA and UA against S. mutans.

Assuntos

Antibacterianos/farmacologia; Vias Biossintéticas/efeitos dos fármacos; Vias Biossintéticas/genética; Ácido Oleanólico/farmacologia; Peptidoglicano/biossíntese; Streptococcus mutans/efeitos dos fármacos; Triterpenos/farmacologia; Regulação Bacteriana da Expressão Gênica/efeitos dos fármacos

Palavras-chave

Oleanolic acid; Peptidoglycan biosynthesis; Streptococcus mutans UA159; Ursolic acid

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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Ácido Oleanólico / Streptococcus mutans / Triterpenos / Peptidoglicano / Vias Biossintéticas / Antibacterianos Idioma: En Revista: Braz. j. microbiol Ano de publicação: 2015 Tipo de documento: Article / Project document

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