Trypanosoma cruzi: experimental Chagas' disease in Rhesus monkeys. II. Ultraestructural and cytochemical studies of peroxidase and acid phosphatase activities
Mem. Inst. Oswaldo Cruz
; 85(2): 173-81, abr.-jun. 1990. ilus
Article
em En
| LILACS
| ID: lil-90850
Biblioteca responsável:
BR15.1
RESUMO
Ultrastructural and cytochemical studies of peroxidase and acid phosphatase were performed in skin, lymph node and heart muscle tissue of thesus monkeys with experimental Chagas's disease. At the site of inoculation ther was a proliferative reaction with the presence of immature macrophages revealed by peroxidase technique. At the lymph node a difuse inflammatory exudate with mononuclear cells, fibroblasts and immature activated macrophages reproduces the human patrtern of acute Chagas' disease inflamatory lesions. The hearth muscle cells present different degrees of degenerative alterations and a striking increase in the number of lysosomal profiles that exhibit acid hydrolase reaction product. A strong inflammatory reaction was present due to lymphocytic infiltrate or due to eosinophil granulocytes associated to ruptured cells. The present study provides some experimental evidences that the monkey model could be used as a reliable model to characterize histopathological alterations of the human disease
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
LILACS
Assunto principal:
Peroxidases
/
Pele
/
Fosfatase Ácida
/
Doença de Chagas
/
Modelos Animais de Doenças
/
Miocárdio
Limite:
Animals
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Ano de publicação:
1990
Tipo de documento:
Article