Incidence of discontinuation of highly active antiretroviral combination therapy (HAART) and its determinants.
J Acquir Immune Defic Syndr Hum Retrovirol
; 20(3): 290-4, 1999 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-10077179
ABSTRACT
OBJECTIVE:
To determine the incidence and determinants for discontinuation of initial highly active antiretroviral therapy (HAART).DESIGN:
In this retrospective follow-up study from hospital files and pharmacy dispensing data, a standard dataset was collected including patient characteristics, therapy characteristics, and HIV-monitoring parameters (e.g., CD4+ lymphocyte counts, viral load determinations). Kaplan-Meier estimates of the cumulative probability of discontinuation of initial HAART were calculated. Cox proportional hazard analysis was used to identify determinants for discontinuation of initial HAART. PATIENTS All patients starting HAART (n = 99) during June 1996 to February 1997 at our regional AIDS center. MAIN OUTCOMEMEASURES:
Incidence and determinants for discontinuation of HAART.RESULTS:
During the mean follow-up of 450+/-10 days, 27 patients switched initial HAART, 3 patients stopped any antiretroviral therapy. Reasons for switching were increasing viral load (18x), insufficient decrease of viral load (3x), and adverse events (6x). Nonnaivete for antiretroviral therapy and a lower CD4+ lymphocyte count at start were identified as determinants for discontinuation of initial HAART.CONCLUSIONS:
The overall incidence density for discontinuation of initial HAART was 25 per 100 patients/year. The main reason for switching was an increasing viral load. CD4+ lymphocyte counts at start and nonnaivete for antiretroviral therapy were identified as determinants for discontinuation.
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Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
Fármacos Anti-HIV
Tipo de estudo:
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Acquir Immune Defic Syndr Hum Retrovirol
Ano de publicação:
1999
Tipo de documento:
Article