Disposition of lantadene A, the pentacyclic triterpenoid hepatotoxin, orally administered to guinea pigs.
Toxicol Lett
; 105(1): 59-66, 1999 Mar 08.
Article
em En
| MEDLINE
| ID: mdl-10092057
ABSTRACT
Lantadene A (LA) administered orally to guinea pigs elicited cholestasis. LA could not be detected in liver, bile, gall bladder, blood and urine. LA and its biotransformation product reduced lantadene A (RLA) could be detected in caecum, large intestine, and faeces. In vitro incubation of LA with liver homogenates under aerobic and anaerobic conditions did not elicit its biotransformation to RLA. On the other hand, in vitro incubation of LA with guinea pig caecal and large intestinal contents under anaerobic conditions elicited conversion of LA to RLA. This is the first report of the biotransformation of LA in the animal system.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Oleanólico
/
Toxinas Biológicas
/
Doença Hepática Induzida por Substâncias e Drogas
Limite:
Animals
Idioma:
En
Revista:
Toxicol Lett
Ano de publicação:
1999
Tipo de documento:
Article