A comparison of manual and semi-automated methods in the assessment of axonal injury.
Neuropathol Appl Neurobiol
; 25(1): 41-7, 1999 Feb.
Article
em En
| MEDLINE
| ID: mdl-10194774
Diffuse axonal injury (DAI) in the central nervous system is a common cause of post-traumatic coma and may result in varying degrees of disability up to and including the vegetative state. Experimental studies in man and animals have previously relied upon semi-quantitative grading systems for determining the relationship between the extent of DAI and the clinical features of patients. Using beta-amyloid precursor protein immunocytochemistry for the detection of DAI in sections of corpus callosum from 15 cases of fatal head injury, we have developed a quantitative image analysis technique for the assessment of axonal injury. This new method is objective and reproducible and should allow better correlation with biomechanical, radiological, and clinical parameters to increase our understanding of DAI.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autoanálise
/
Axônios
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Processamento de Imagem Assistida por Computador
/
Imuno-Histoquímica
/
Traumatismos Craniocerebrais
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
/
Evaluation_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Neuropathol Appl Neurobiol
Ano de publicação:
1999
Tipo de documento:
Article