Radiation myelopathy with partial functional recovery: PET evidence of long-term increased metabolic activity of the spinal cord.
J Neurol Sci
; 163(1): 39-43, 1999 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-10223408
ABSTRACT
Postoperative telecobalt irradiation was performed with a biologically effective extrapolated response dose of 165 Gy2 delivered to the spinal cord of a papillary thyroid cancer patient. Incomplete cervical transection developed, followed by a gradual functional improvement, which is still continuing 8 years after radiotherapy. Between the 6th and 8th years of the clinical course, positron emission tomography investigations demonstrated an increased 18F-deoxyglucose accumulation and (15)O-butanol perfusion, but negligible 11C-methionine uptake in the irradiated spinal cord segment. We suggest that the increased metabolism and perfusion, and the lack of detectable protein synthesis may be related to the increased energy demands of action potential conduction, due to the higher than normal density of sodium channels along demyelinated axons displaying restored conduction.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Radioterapia
/
Medula Espinal
/
Neoplasias da Glândula Tireoide
/
Carcinoma Papilar
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
J Neurol Sci
Ano de publicação:
1999
Tipo de documento:
Article