Defective human T-lymphotrophic virus type I provirus in T-cell prolymphocytic leukaemia.
Br J Haematol
; 105(2): 376-81, 1999 May.
Article
em En
| MEDLINE
| ID: mdl-10233407
ABSTRACT
T-cell prolymphocytic leukaemia (T-PLL) is a rare form of post-thymic T-cell neoplasm, the aetiology of which remains unknown. We examined human T-lymphotropic virus (HTLV) provirus in five HTLV-I/II seronegative patients with T-PLL. Southern blotting did not show monoclonal integration of the HTLV-I genome in any of the DNA samples. However, two of the five DNA samples contained an HTLV-I tax sequence. Other sets of oligonucleotide primers for HTLV-I gag, pol, env and LTR regions were all negative. HTLV-I tax gene expression and p40tax antibody were not detected in samples from cases with HTLV-I tax sequence. Our findings suggest that there may be alternative mechanisms involved in HTLV-associated leukaemogenesis, in which HTLV-I genome insertion triggers T-PLL but the deletion of various regions of the integrated provirus subsequently prevents active replication and the expression of the virus.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA Viral
/
Vírus Linfotrópico T Tipo 1 Humano
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Leucemia Prolinfocítica
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Leucemia de Células T
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Produtos do Gene tax
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Provírus
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Idioma:
En
Revista:
Br J Haematol
Ano de publicação:
1999
Tipo de documento:
Article