Increased replication of Sendai virus in morphine-treated epithelial cells: evidence for the involvement of the intracellular levels of glutathione.
Int J Immunopharmacol
; 21(3): 185-93, 1999 Mar.
Article
em En
| MEDLINE
| ID: mdl-10348368
ABSTRACT
This paper shows that morphine increases Sendai virus replication in cultured epithelial cells. The effect was maximal when it was added before viral infection. Morphine also reduced the intracellular level of glutathione, namely, the oxidative and most abundant cell thiol. Altered intracellular redox status has recently been proposed as a factor influencing viral infection. Support for this view was provided by our data showing that inhibition of de novo glutathione synthesis, using L-buthionine sulfoximine, increased virus replication. These findings provide the first evidence that morphine increases the susceptibility to virus infection by altering the intracellular levels of glutathione.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Replicação Viral
/
Respirovirus
/
Células Epiteliais
/
Glutationa
/
Analgésicos Opioides
/
Morfina
Limite:
Animals
Idioma:
En
Revista:
Int J Immunopharmacol
Ano de publicação:
1999
Tipo de documento:
Article