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Detection and clinical significance of plasma glutathione-S-transferases in dogs with lymphoma.
Hahn, K A; Barnhill, M A; Freeman, K P; Shoieb, A M.
Afiliação
  • Hahn KA; Department of Comparative Medicine, College of Veterinary Medicine, University of Tennessee, Knoxville 37901-1071, USA.
In Vivo ; 13(2): 173-5, 1999.
Article em En | MEDLINE | ID: mdl-10363174
BACKGROUND: The objective of this study was to determine if glutathione-S-transferases were detectable in the plasma of dogs and to determine if concentrations of the a- and pi-subtypes were related with tumor response to single agent anthracycline (e.g., doxorubicin) chemotherapy in dogs with lymphoma. MATERIALS AND METHODS: Plasma was obtained from 10 healthy, normal dogs and from 11 dogs with lymphoma before treatment, 3 weeks after 1 dose of doxorubicin and every 3 weeks thereafter until relapse (the physical detection of recurrent and enlarged peripheral lymph nodes). Plasma concentration of alpha and pi-GST was determined by use of an ELISA technique with well plates pre-coated with IgG[anti-Canine alpha-GST or anti-Human pi-GST]. RESULTS: Mean plasma alpha-GST concentrations did not significantly decline after 1 dose of doxorubicin chemotherapy; however, mean plasma alpha-GST concentrations were markedly increased (p < 0.05) at the time of relapse (the physical detection of recurrent and enlarged peripheral lymph nodes). CONCLUSIONS: In this study we show that a relationship exists between the plasma alpha-GST concentration and the clinical response of dogs with lymphoma to doxorubicin chemotherapy.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças do Cão / Leucemia-Linfoma Linfoblástico de Células Precursoras / Glutationa Transferase Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: In Vivo Ano de publicação: 1999 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças do Cão / Leucemia-Linfoma Linfoblástico de Células Precursoras / Glutationa Transferase Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: In Vivo Ano de publicação: 1999 Tipo de documento: Article