The subgenus-specific C-terminal region of protein IX is located on the surface of the adenovirus capsid.
J Virol
; 73(7): 6182-7, 1999 Jul.
Article
em En
| MEDLINE
| ID: mdl-10364380
ABSTRACT
We have investigated the antigenicity of the C- and N-terminal halves of pIX of human adenovirus types 2 and 3 (Ad2 and Ad3) as well as their orientations in virions. We found that only the C-terminal halves of Ad2 pIX and Ad3 pIX reacted in a subgenus-specific manner by enzyme-linked immunosorbent assay and immunoblot analysis. Based on immunoelectron microscopy experiments, pIX in viral capsids appears to be positioned such that the C-terminal part of pIX constitutes the surface domain whereas the N terminus of the protein makes up the internal domain in icosahedral Ad capsids.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adenovírus Humanos
/
Capsídeo
/
Proteínas do Capsídeo
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Antígenos Virais
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Virol
Ano de publicação:
1999
Tipo de documento:
Article