Intranasal murine model of Bordetella pertussis infection. I. Prediction of protection in human infants by acellular vaccines.
Vaccine
; 17(19): 2366-76, 1999 May 14.
Article
em En
| MEDLINE
| ID: mdl-10392618
ABSTRACT
Bicomponent, tricomponent and pertactin DTPa vaccines were tested in sublethal aerosol, and lethal and sublethal intranasal murine Bordetella pertussis respiratory challenge models. Pertactin and bicomponent vaccines induced protective immunity against lethality but with little or no bacterial clearance. Intranasal challenge discriminated in a reproducible, statistically significant manner between the efficacies of bicomponent and tricomponent DTPa, in agreement with clinical trial data. This discrimination was not observed in the aerosol challenge. Pertactin had a synergistic effect with bicomponent DTPa. Intranasal challenge may be useful as part of the preclinical evaluation of new acellular pertussis formulations or DTPa-based combinations.
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Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
/
6_ODS3_enfermedades_notrasmisibles
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7_ODS3_muertes_prevenibles_nacidos_ninos
Base de dados:
MEDLINE
Assunto principal:
Bordetella pertussis
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Vacina contra Difteria, Tétano e Coqueluche
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Coqueluche
Tipo de estudo:
Clinical_trials
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Prognostic_studies
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Risk_factors_studies
Limite:
Animals
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Female
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Humans
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Infant
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Newborn
Idioma:
En
Revista:
Vaccine
Ano de publicação:
1999
Tipo de documento:
Article