Inhibition of aromatase activity by flavonoids.
Arch Pharm Res
; 22(3): 309-12, 1999 Jun.
Article
em En
| MEDLINE
| ID: mdl-10403137
ABSTRACT
In searching for potent cancer chemopreventive agents from synthetic or natural products, 28 randomly selected flavonoids were screened for inhibitory effects against partially purified aromatase prepared from human placenta. Over 50% of the flavonoids significantly inhibited aromatase activity, with greatest activity being demonstrated with apigenin (IC50 0.9 microg/mL), chrysin (IC50 1.1 microg/mL), and hesperetin (IC50 1.0 microg/mL).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Placenta
/
Flavonoides
/
Aromatase
/
Microssomos
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Arch Pharm Res
Ano de publicação:
1999
Tipo de documento:
Article