Childbearing history associated with improved survival in choroidal melanoma.
Arch Ophthalmol
; 117(7): 939-42, 1999 Jul.
Article
em En
| MEDLINE
| ID: mdl-10408460
ABSTRACT
BACKGROUND:
Research in cutaneous melanoma suggests that women may experience better tumor-dependent survival than men, and some studies have shown that the advantage is specific to childbearing.OBJECTIVE:
To examine whether childbearing may be a favorable prognostic factor in melanoma of the uveal tract.DESIGN:
Prospective follow-up study.SETTING:
Hospital. MAIN OUTCOMEMEASURE:
Death from metastatic choroidal melanoma.METHODS:
We evaluated a consecutive series of 1818 patients with choroidal melanoma, 748 parous and 165 nulliparous women and 905 men, after treatment with proton irradiation. Three hundred fifty-two deaths from metastasis were documented in follow-up.RESULTS:
Overall multivariate-adjusted death rates from metastasis were approximately 25% higher in nulliparous women (relative risk [RR], 1.23; 95% confidence interval [CI], 0.83-1.82) and men (RR, 1.25; 95% CI, 1.00-1.56) than in women who had given birth. The protective influence of parity was strongest in the early period following diagnosis and treatment (RR, 1.58; 95% CI, 0.88-2.86, and RR, 1.51; 95% CI, 1.04-2.19, in nulliparous women and men, respectively, during the first 36 months of follow-up). The level of protection increased with the number of live births (P for trend, .04).CONCLUSION:
These data provide support for the hypothesis that a history of childbearing confers protection from death in choroidal melanoma.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Coroide
/
História Reprodutiva
/
Melanoma
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
/
Pregnancy
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Arch Ophthalmol
Ano de publicação:
1999
Tipo de documento:
Article