Endothelin receptor antagonists reduce the pressor effects of angiotensin II into the periaqueductal gray area of rats.
Life Sci
; 65(9): PL95-9, 1999.
Article
em En
| MEDLINE
| ID: mdl-10465357
ABSTRACT
Injection of ANGII (0.01, 0.1 and 1 nmol/rat) into the periaqueductal gray (PAG) area significantly (P<0.01) increased, in a dose-dependent manner, the mean arterial blood pressure (MAP). The increases in blood pressure induced by ANGII (1 nmol; 37 +/- 4 mmHg, n=5) were greatly reduced (>85%) by pre-administration of the ET(A) receptor antagonist FR139317 (5 nmol/rat) to the PAG area, but were unaffected by the ET(B) receptor antagonist BQ-788 (5 nmol/rat). SB209670, non-selective ET(A)/ET(B) receptor antagonist, also reduced the effect induced by ANGII. These results suggest that endogenous endothelin-1, via an action on ET(A) receptors, may contribute to the pressor effects of ANGII within the PAG area of rats.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pressão Sanguínea
/
Angiotensina II
/
Substância Cinzenta Periaquedutal
/
Antagonistas dos Receptores de Endotelina
Limite:
Animals
Idioma:
En
Revista:
Life Sci
Ano de publicação:
1999
Tipo de documento:
Article