Cisplatin-resistant derivatives of murine L1210 leukemia cells are not susceptible to growth-inhibiting and apoptosis-inducing actions of transforming growth factor-beta1.
Anticancer Drugs
; 10(5): 457-63, 1999 Jun.
Article
em En
| MEDLINE
| ID: mdl-10477165
ABSTRACT
Murine L1210 leukemia cells possessing an increased resistance to cisplatin were found to be refractory to transforming growth factor (TGF)-beta1-induced growth inhibition, while the parental L1210 cells were strongly inhibited by this cytokine. Growth inhibition was estimated on the basis of [3H]thymidine incorporation, cell counting and colony-forming assay. Cisplatin-resistant L1210 cells were also shown to be much more resistant than the parental cells to both cisplatin- and TGF-beta1-induced apoptosis. These results suggest the existence of cross-resistance to cisplatin and TGF-beta1 in the studied leukemia cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucemia L1210
/
Fator de Crescimento Transformador beta
/
Cisplatino
/
Apoptose
/
Antineoplásicos
Limite:
Animals
Idioma:
En
Revista:
Anticancer Drugs
Ano de publicação:
1999
Tipo de documento:
Article