Effect of amlodipine on exercise-induced platelet activation in patients affected by chronic stable angina.
Clin Cardiol
; 22(9): 575-80, 1999 Sep.
Article
em En
| MEDLINE
| ID: mdl-10486696
ABSTRACT
BACKGROUND:
Literature concerning exercise-induced platelet activation in chronic stable angina is somewhat confusing. The reason lies in the type of exercise as well as in methodological problems. A powerful, recently introduced procedure to detect platelet activation is flow cytometry. Platelet response to activating factors is mediated by calcium uptake; however, calcium antagonist effect on platelet activity is still unclear.HYPOTHESIS:
The study was undertaken to investigate exercise-induced platelet activation before and after treatment with amlodipine in chronic stable angina.METHODS:
Twenty patients with chronic stable angina were entered into the study. Each subject underwent a symptom-limited cycloergometer stress test following a washout period of 2 weeks. Blood samples were collected before and immediately after exercise. All subjects were then randomized into two groups of 10 patients each, with Group 1 and Group 2 taking amlodipine 10 mg/day, and placebo for 4 weeks, respectively. They subsequently underwent a second exercise stress test, and blood samples were obtained before and immediately after exercise. Flow-cytometric evaluation of platelet activity was performed in order to recognize GMP-140 expression on platelet membrane.RESULTS:
Strenuous exercise induced a significant increase in platelet activation in all subjects prior to therapy. No significant differences were observed in platelet activity at rest between Groups 1 and 2, whereas a significant decrease in exercise-induced platelet activation was demonstrated in Group 1 compared with Group 2.CONCLUSION:
Our data provide evidence of the favorable effect of amlodipine on exercise-induced platelet activation in patients affected by chronic stable angina.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bloqueadores dos Canais de Cálcio
/
Exercício Físico
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Ativação Plaquetária
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Anlodipino
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Angina Pectoris
Tipo de estudo:
Clinical_trials
Limite:
Aged
/
Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Clin Cardiol
Ano de publicação:
1999
Tipo de documento:
Article