Antisecretory effect of peptide YY through neural receptors in the rat jejunum in vitro.
Peptides
; 20(8): 987-93, 1999.
Article
em En
| MEDLINE
| ID: mdl-10503778
ABSTRACT
Basal short circuit current (Isc) was measured in stripped rat jejunum after addition of neural antagonists and of peptide YY (PYY). Basal Isc was slightly (by 10-21%) but significantly inhibited by tetrodotoxin, hexamethonium, idazoxan, and the sigma antagonist BMY 14,802. PYY (10(-7) M) reduced basal Isc by approximately 54%. This inhibition was unchanged by hexamethonium but reduced by 44-68% in the presence of tetrodotoxin, idazoxan, haloperidol, BMY 14,802, and atropine. The Y2 agonist pYY(3-36) was more potent than the Y1 agonist (Leu31,Pro34)PYY. In conclusion, PYY reduces basal Isc in rat jejunum in part through a neural mechanism involving muscarinic receptors, alpha2 adrenoceptors, and sigma receptors and, in part, through a direct effect on enterocytes. The PYY effect seems mainly carried out through Y2-receptor activation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeo YY
/
Jejuno
Limite:
Animals
Idioma:
En
Revista:
Peptides
Ano de publicação:
1999
Tipo de documento:
Article