PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance.
Mol Cell
; 4(4): 597-609, 1999 Oct.
Article
em En
| MEDLINE
| ID: mdl-10549291
ABSTRACT
Agonist-induced activation of peroxisome proliferator-activated receptor gamma (PPAR gamma) is known to cause adipocyte differentiation and insulin sensitivity. The biological role of PPAR gamma was investigated by gene targeting. Homozygous PPAR gamma-deficient embryos died at 10.5-11.5 dpc due to placental dysfunction. Quite unexpectedly, heterozygous PPAR gamma-deficient mice were protected from the development of insulin resistance due to adipocyte hypertrophy under a high-fat diet. These phenotypes were abrogated by PPAR gamma agonist treatment. Heterozygous PPAR gamma-deficient mice showed overexpression and hypersecretion of leptin despite the smaller size of adipocytes and decreased fat mass, which may explain these phenotypes at least in part. This study reveals a hitherto unpredicted role for PPAR gamma in high-fat diet-induced obesity due to adipocyte hypertrophy and insulin resistance, which requires both alleles of PPAR gamma.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Resistência à Insulina
/
Receptores Citoplasmáticos e Nucleares
/
Adipócitos
/
Tiazolidinedionas
/
Tamanho Celular
/
Gorduras
Limite:
Animals
Idioma:
En
Revista:
Mol Cell
Ano de publicação:
1999
Tipo de documento:
Article