Right ventricular function after pulmonary autograft replacement of the aortic valve.
Circulation
; 100(19 Suppl): II36-41, 1999 Nov 09.
Article
em En
| MEDLINE
| ID: mdl-10567276
ABSTRACT
BACKGROUND:
The pulmonary autograft operation (the Ross procedure) involves excision of a portion of the right ventricular (RV) outflow tract, prolonged cross-clamp times, and insertion of a pulmonary homograft. There is concern about the effect of such operations on right ventricular function. METHODS ANDRESULTS:
Twenty-five patients undergoing either pulmonary autograft or homograft replacement of the aortic valve as part of a prospective randomized trial had echocardiographic RV long-axis measurements performed before surgery and 6 months (range 3 to 12 months) after surgery. In all patients, systolic excursion (SE) and both shortening and lengthening rates (SR and LR, respectively) were reduced postoperatively (P<0.05) (homografts SE 1.5+/-0.4 versus 2.3+/-0.6 cm, SR 6.8+/-2.1 versus 9. 6+/-3.1 cm/s, LR 6.0+/-1.8 versus 8.9+/-3.0 cm/s; autografts SE 1. 4+/-0.4 versus 2.2+/-0.4 cm, SR 5.8+/-3.0 versus 8.2+/-3.0 cm/s, LR 5.7+/-1.9 versus 8.5+/-3.7 cm/s). There were no differences between the 2 groups. Eighteen patients who had undergone either aortic homograft or pulmonary autograft surgery were studied between 6 and 35 months after surgery. RV volumes were assessed with the use of MRI in addition to echocardiographic RV long-axis measurements. Global volumes were increased to a similar amount in both groups (homografts end-diastolic volume 145+/-34 mL, end-systolic volume 78+/-23 mL; autografts end-diastolic volume 157+/-33 mL, end-systolic volume 89+/-25 mL; P=NS), whereas stroke volumes were maintained in both groups (homografts 67+/-15 mL, autografts 67+/-16 mL; P=NS). RV SE was depressed in both groups to a similar degree to that seen with the previous group (homografts 1.5+/-0.3 cm, autografts 1.4+/-0.2 cm).CONCLUSIONS:
Aortic valve replacement with either a pulmonary autograft or an aortic homograft leads to a degree of persistent RV longitudinal dysfunction that is not more pronounced in those undergoing the Ross procedure. The mechanisms and long-term effects of these changes must be further studied.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Valva Aórtica
/
Bioprótese
/
Próteses Valvulares Cardíacas
/
Função Ventricular Direita
/
Implante de Prótese de Valva Cardíaca
/
Pulmão
Tipo de estudo:
Clinical_trials
/
Observational_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Circulation
Ano de publicação:
1999
Tipo de documento:
Article