Absence of G209A and G88C mutations in the alpha-synuclein gene of Parkinson's disease in a Chinese population.
Eur Neurol
; 42(4): 217-20, 1999.
Article
em En
| MEDLINE
| ID: mdl-10567818
ABSTRACT
A G209A mutation in the alpha-synuclein gene was recently discovered in a large Italian kindred and three unrelated Greek kindreds with autosomal dominant Parkinson's disease (PD). Subsequently, another mutation in the gene (G88C) was also identified in a German family with autosomal PD. These results indicate that the alpha-synuclein gene may have an important role in the pathogenesis of PD. This study was designed to screen the existence of both mutations of the alpha-synuclein gene among 100 Chinese patients with PD, including 80 with sporadic and 20 with familial PD. Results showed that none of our patients, both sporadic and familial PD, had either of the two mutations of this gene. We therefore conclude that although of great interest, these two mutations are not relevant for the pathogenesis of PD in a Han Chinese population.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Fosfoproteínas
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Mutação Puntual
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Povo Asiático
/
Proteínas do Tecido Nervoso
Limite:
Aged
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Female
/
Humans
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Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Eur Neurol
Ano de publicação:
1999
Tipo de documento:
Article