Vitamin E and infectious diseases in the aged.
Proc Nutr Soc
; 58(3): 697-705, 1999 Aug.
Article
em En
| MEDLINE
| ID: mdl-10604205
ABSTRACT
The incidence of infectious diseases, particularly respiratory diseases, increases with age. Age-associated decline in immune function contributes to the increased susceptibility of the aged to infections. Vitamin E supplementation has been shown to improve some aspects of immune function in aged animals and human subjects. The protective effect of vitamin E against viral or bacterial infections in experimentally-challenged young animals has been reported. We investigated the effects of supplementation with vitamin E and other antioxidants on resistance to influenza infection in young and old animals. While vitamin E-supplemented young mice showed only a modest reduction in lung viral titre, vitamin E-supplemented old mice exhibited a highly significant (P < 0.05) reduction in viral lung titre. In subsequent studies, we focused on the mechanism of vitamin E-induced reduction of influenza viral titre. The results of these studies as well as those reported by other investigators on the relationship between vitamin E and infectious diseases will be reviewed.
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Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Vitamina E
/
Envelhecimento
/
Infecções
Limite:
Aged
/
Animals
/
Humans
Idioma:
En
Revista:
Proc Nutr Soc
Ano de publicação:
1999
Tipo de documento:
Article