A RhoA-derived peptide inhibits syncytium formation induced by respiratory syncytial virus and parainfluenza virus type 3.
Nat Med
; 6(1): 35-40, 2000 Jan.
Article
em En
| MEDLINE
| ID: mdl-10613821
ABSTRACT
The fusion glycoproteins of human respiratory syncytial virus (RSV) and human parainfluenza virus type-3 (PIV-3) mediate virus entry and syncytium formation. Interaction between the fusion protein of RSV and RhoA, a small GTPase, facilitates virus-induced syncytium formation. We show here a RhoA-derived peptide inhibits RSV and syncytium formation induced by RSV and PIV-3, both in vitro by inhibition of cell-to-cell fusion and in vivo by reduction of peak titer by 2 log10 in RSV-infected mice. These findings indicate that the interaction between these two paramyxovirus fusion proteins and RhoA is an important target for new antiviral strategies.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
4_TD
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Células Gigantes
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Vírus Sincicial Respiratório Humano
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Infecções por Vírus Respiratório Sincicial
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Vírus da Parainfluenza 3 Humana
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Proteína rhoA de Ligação ao GTP
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Med
Ano de publicação:
2000
Tipo de documento:
Article