Spectrophotometric determination of some antidepressant drugs using 3-methylbenzothiazolin-2-one hydrazone.
Eur J Pharm Sci
; 9(2): 221-5, 1999 Dec.
Article
em En
| MEDLINE
| ID: mdl-10620735
ABSTRACT
A sensitive spectrophotometric method for the determination of amitriptyline hydrochloride, nortriptyline hydrochloride and doxepin hydrochloride in pure and dosage forms, is described. The method is based on the oxidative coupling of the drugs with 3-methylbenzothiazolin-2-one hydrazone in the presence of iron(III) chloride in 1 M hydrochloric acid. The commonly encountered excipients and additives do not interfere with the determinations. Results of the present method are comparable with those of official methods. The new method offers the advantage of simplicity and rapidity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Espectrofotometria
/
Tiazóis
/
Compostos Férricos
/
Doxepina
/
Amitriptilina
/
Antidepressivos
/
Nortriptilina
Idioma:
En
Revista:
Eur J Pharm Sci
Ano de publicação:
1999
Tipo de documento:
Article