Presenilin mutants subvert chaperone function.
Nat Cell Biol
; 2(2): E21-3, 2000 Feb.
Article
em En
| MEDLINE
| ID: mdl-10655596
ABSTRACT
Mutant presenilin proteins, known to promote the development of Alzheimer's disease through increased generation of Abeta42 peptides, appear to compound this insult by downregulating the signalling pathway that adjusts levels of molecular chaperones in the endoplasmic reticulum in response to stress.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Chaperonas Moleculares
/
Doença de Alzheimer
/
Proteínas de Membrana
/
Mutação
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Nat Cell Biol
Ano de publicação:
2000
Tipo de documento:
Article