Effect of eating on plasma radical-trapping antioxidant activity (TRAP) in patients with cirrhosis.
Clin Biochem
; 32(6): 447-53, 1999 Aug.
Article
em En
| MEDLINE
| ID: mdl-10667480
ABSTRACT
OBJECTIVES:
To ascertain the effects of eating on plasma antioxidant capacity in patients with liver disease. DESIGN ANDMETHODS:
Eighteen cirrhotic patients were compared to 18 age and sex-matched controls. TRAP was measured by a fluorometric assay after a 12 h fast, and 60, 120, and 180 min after the study participants had taken a drink formula food.RESULTS:
In the fasting state, TRAP was higher in patients with alcoholic cirrhosis (847+/-39 micromol/L, mean +/- SEM) in comparison to patients with viral cirrhosis (653+/-41) and to controls (758+/-26) (p<0.005). In cirrhotic patients, TRAP did not change in the post-absorptive state. In controls, TRAP decreased progressively, to a value of 719+/-21 (p<0.02), and the AUC of the delta-values of TRAP and of plasma insulin showed an inverse correlation (r = -0.52, p<0.05).CONCLUSIONS:
In normal subjects, but not in cirrhotics, TRAP decreases in the post-absorptive state, probably in relationship with the activation of metabolic pathways.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ingestão de Alimentos
/
Cirrose Hepática
/
Antioxidantes
Tipo de estudo:
Observational_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Biochem
Ano de publicação:
1999
Tipo de documento:
Article