Screening of selected plant extracts for in vitro inhibitory activity on HIV-1 reverse transcriptase (HIV-1 RT).
Pharmazie
; 55(1): 75-7, 2000 Jan.
Article
em En
| MEDLINE
| ID: mdl-10683878
ABSTRACT
Methanolic-aqueous extracts of 70 plants were investigated for their ability to inhibit HIV-1 reverse transcriptase activity in vitro. Two thirds of the extracts screened showed more than 50% inhibition. Two extracts inhibited the enzyme completely while four exhibited more than 90% inhibition. Tannins as nonspecific HIV-1 RT inhibitors were detected and removed from the extracts. The IC50 values of the most potent extracts after the removal of tannins for the HIV-1 RT inhibition are as follows Sambucus racemosa 0.017 mg/ml and Geranium phaeum 0.067 mg/ml. Daunomycine was chosen as a standard substance in the non-radioactive immuno assay used for screening. As a result from the future isolation and characterization of these compounds, new leading structures are expectable.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
/
Inibidores da Transcriptase Reversa
/
Transcriptase Reversa do HIV
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Idioma:
En
Revista:
Pharmazie
Ano de publicação:
2000
Tipo de documento:
Article