Prevention of mother-to-child HIV transmission in resource-poor countries: translating research into policy and practice.
JAMA
; 283(9): 1175-82, 2000 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-10703780
ABSTRACT
Each year, an estimated 590,000 infants acquire human immunodeficiency virus type 1 (HIV) infection from their mothers, mostly in developing countries that are unable to implement interventions now standard in the industrialized world. In resource-poor settings, the HIV pandemic has eroded hard-won gains in infant and child survival. Recent clinical trial results from international settings suggest that short-course antiretroviral regimens could significantly reduce perinatal HIV transmission worldwide if research findings could be translated into practice. This article reviews current knowledge of mother-to-child HIV transmission in developing countries, summarizes key findings from the trials, outlines future research requirements, and describes public health challenges of implementing perinatal HIV prevention interventions in resource-poor settings. Public health efforts must also emphasize primary prevention strategies to reduce incident HIV infections among adolescents and women of childbearing age. Successful implementation of available perinatal HIV interventions could substantially improve global child survival.
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Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
/
4_TD
/
7_ODS3_muertes_prevenibles_nacidos_ninos
Base de dados:
MEDLINE
Assunto principal:
Complicações Infecciosas na Gravidez
/
Infecções por HIV
/
Transmissão Vertical de Doenças Infecciosas
/
Países em Desenvolvimento
Tipo de estudo:
Clinical_trials
Aspecto:
Determinantes_sociais_saude
Limite:
Adolescent
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Adult
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Female
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Humans
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Infant
/
Pregnancy
Idioma:
En
Revista:
JAMA
Ano de publicação:
2000
Tipo de documento:
Article