The interferon-induced gene ISG12 is regulated by various cytokines as the gene 6-16 in human cell lines.
Cytokine
; 12(3): 233-8, 2000 Mar.
Article
em En
| MEDLINE
| ID: mdl-10704250
ABSTRACT
The gene for ISG12 (originally designated p27) was isolated as an oestrogen-induced gene. The authors undertook a comprehensive study using quantitative RT-PCR, in which we delineate the regulation of ISG12 by seven different cytokines including interferons and poly(I). poly(C) in seven human cell lines of different origin. In all cell lines ISG12 is strongly induced by IFN-alpha and only slightly by IFNgamma. Poly(I).poly(C) induces ISG12 in a cell line-dependent manner, whereas none of the other cytokines tested elicited a response. Comparing the induction pattern of ISG12 to that of 6-16 a high degree of similarity was found. The induction levels varied, however, between cell lines.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Regulação da Expressão Gênica
/
Citocinas
/
Interferons
Limite:
Humans
Idioma:
En
Revista:
Cytokine
Ano de publicação:
2000
Tipo de documento:
Article