Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling.
Genes Dev
; 14(6): 650-4, 2000 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-10733525
ABSTRACT
Female reproductive hormones control mammary gland morphogenesis. In the absence of the progesterone receptor (PR) from the mammary epithelium, ductal side-branching fails to occur. We can overcome this defect by ectopic expression of the protooncogene Wnt-1. Transplantation of mammary epithelia from Wnt-4(-)/(-) mice shows that Wnt-4 has an essential role in side-branching early in pregnancy. PR and Wnt-4 mRNAs colocalize to the luminal compartment of the ductal epithelium. Progesterone induces Wnt-4 in mammary epithelial cells and is required for increased Wnt-4 expression during pregnancy. Thus, Wnt signaling is essential in mediating progesterone function during mammary gland morphogenesis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Progesterona
/
Transdução de Sinais
/
Proteínas Proto-Oncogênicas
/
Glândulas Mamárias Animais
Limite:
Animals
Idioma:
En
Revista:
Genes Dev
Ano de publicação:
2000
Tipo de documento:
Article