Synthesis and antitumour activity of a new series of nitrosoureido sugars.
Eur J Med Chem
; 35(1): 137-46, 2000 Jan.
Article
em En
| MEDLINE
| ID: mdl-10733610
ABSTRACT
New nitrosoureido derivatives of di- or tri-deoxy-sugars have been synthesized. Very potent antitumour activity against L1210 leukaemia was exhibited by the compounds derived from methyl 3-amino-3, 4-dideoxy-beta- and alpha- and 4-amino-2,4-dideoxy-beta- and alpha-D-arabino-hexopyranosides, 24, 26, 28 and 29, respectively. In further evaluation against B16 melanocarcinoma bearing mice, only compounds 24 and 26 displayed significant activity. Owing to its lower acute toxicity, methyl 3-[3-(2-chloroethyl)-3-nitrosoureido]-3, 4-dideoxy-beta-D-arabino-hexopyranoside 24 appeared as the best candidate for preclinical studies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glucosídeos
/
Antineoplásicos
/
Compostos de Nitrosoureia
Limite:
Animals
Idioma:
En
Revista:
Eur J Med Chem
Ano de publicação:
2000
Tipo de documento:
Article