Lactoferrin protects against UV-B irradiation-induced corneal epithelial damage in rats.
Cornea
; 19(2): 207-11, 2000 Mar.
Article
em En
| MEDLINE
| ID: mdl-10746454
ABSTRACT
PURPOSE:
Lactoferrin supplementation suppresses ultraviolet light B (UV-B)-induced oxidation of cultures of human corneal epithelial cells. To investigate the protective effect of lactoferrin containing eyedrops against UV-B-induced corneal damage in vivo, we examined lactoferrin efficacy in a rat UV-B keratitis model.METHODS:
Sprague-Dawley rats were irradiated with >10 kJ/m2 after anesthetization, and then corneal epithelial defect was observed at 24 h postirradiation. The pre- or postapplication of vehicle or lactoferrin-containing eyedrops was performed, and then corneal epithelial damage was scored based on fluorescein staining.RESULTS:
Posttreatment with lactoferrin did not inhibit the extent of corneal damage and did not affect wound healing. However, pretreatment by topical application of lactoferrin suppressed development of a corneal epithelial defect induced by UV-B irradiation in rats.CONCLUSION:
These results suggest that the presence of lactoferrin in human tear fluid may inhibit UV-induced corneal epithelial damage.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lesões Experimentais por Radiação
/
Raios Ultravioleta
/
Epitélio Corneano
/
Ceratite
/
Lactoferrina
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Cornea
Ano de publicação:
2000
Tipo de documento:
Article