Evaluation of T-cell response to CD3 plus CD28 monoclonal antibodies in HIV-1 infected subjects treated with highly active antiretroviral therapy.
J Biol Regul Homeost Agents
; 14(1): 38-40, 2000.
Article
em En
| MEDLINE
| ID: mdl-10763891
ABSTRACT
To investigate whether highly active antiretroviral therapy (HAART) could improve CD28 molecule expression and CD28-costimulation pathway function we tested the effect of CD28-costimulation on T cell receptor/CD3 induced proliferative responses in a group of HIV-1-infected subjects with CD4+ cells>200/mmc before and after HAART. CD3-mediated responses are recovered or improved after HAART. However the ability of potentiating the responses through CD28-costimulation seemed conserved before therapy and decreased in parallel with increase of response to CD3 alone. These results confirm the integrity of CD28-pathway of costimulation in patients with CD4+ cells>200/mmc and suggest an inverse correlation between magnitude of response to CD3 alone and increase of CD3 response due to anti-CD28 addition.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Síndrome da Imunodeficiência Adquirida
/
HIV-1
/
Complexo CD3
/
Antígenos CD28
/
Fármacos Anti-HIV
/
Anticorpos Monoclonais
Limite:
Humans
Idioma:
En
Revista:
J Biol Regul Homeost Agents
Ano de publicação:
2000
Tipo de documento:
Article