Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation.
J Virol
; 74(10): 4894-7, 2000 May.
Article
em En
| MEDLINE
| ID: mdl-10775631
ABSTRACT
We report that lysosomotropic agents and cysteine protease inhibitors inhibited protease-resistant prion protein accumulation in scrapie-infected neuroblastoma cells. The inhibition occurred without either apparent effects on normal prion protein biosynthesis or turnover or direct interactions with prion protein molecules. The findings introduce two new classes of inhibitors of the formation of protease-resistant prion protein.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quinacrina
/
Inibidores de Cisteína Proteinase
/
Proteínas PrPSc
/
Leucina
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
J Virol
Ano de publicação:
2000
Tipo de documento:
Article