Sex in the wormcounting and compensating X-chromosome dose.
Trends Genet
; 16(6): 247-53, 2000 Jun.
Article
em En
| MEDLINE
| ID: mdl-10827451
ABSTRACT
The nematode Caenorhabditis elegans counts its X chromosomes to determine sex and to activate the process of dosage compensation, which ensures that males (XO) and hermaphrodites (XX) express equal levels of most X-chromosome products. The number of X chromosomes is communicated by a set of X-linked genes called X-signal elements, which repress the master sex-determination switch gene xol-1 via two distinct, dose-dependent molecular mechanisms in XX embryos. X-chromosome gene dosage is compensated by a specialized protein complex that includes evolutionarily conserved components of mitotic and meiotic machinery. This complex assembles on both X chromosomes of hermaphrodites to repress transcription by half. The recruitment of chromosome segregation proteins to the new task of regulating X-chromosome-wide gene expression points to the evolutionary origin of nematode dosage compensation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromossomo X
/
Mecanismo Genético de Compensação de Dose
/
Caenorhabditis elegans
Limite:
Animals
Idioma:
En
Revista:
Trends Genet
Ano de publicação:
2000
Tipo de documento:
Article