Lack of substantial effect of the H(3)-antagonist thioperamide and of the non-selective mixed H(3)-antagonist/H(1)-agonist betahistine on amygdaloid kindled seizures.
Epilepsy Res
; 40(2-3): 141-5, 2000 Jul.
Article
em En
| MEDLINE
| ID: mdl-10863141
ABSTRACT
We investigated whether some histamine H(3)-antagonists would attenuate amygdaloid kindled seizures in rats. Thioperamide, a standard H(3)-antagonist, did not significantly reduce either seizure ranks or afterdischarge duration (ADD). Betahistine which has both H(3)-antagonistic activity and H(1)-agonistic activity significantly reduced ADD, albeit mild at a toxic dose, though seizure ranks were not affected. In addition, L-histidine, the precursor of histamine, affected neither seizure ranks, nor ADD. It was shown that H(3)-antagonists have no significant inhibitory action against amygdaloid kindled seizures, probably because released histamine was unable to inhibit those seizures.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Beta-Histina
/
Agonistas dos Receptores Histamínicos
/
Antagonistas dos Receptores Histamínicos
/
Excitação Neurológica
Limite:
Animals
Idioma:
En
Revista:
Epilepsy Res
Ano de publicação:
2000
Tipo de documento:
Article