Establishment of an immunocompetent nipple valve anastomosis to prevent faecal reflux after ileocolic resection in dogs.
Eur J Surg
; 166(5): 409-14, 2000 May.
Article
em En
| MEDLINE
| ID: mdl-10881955
ABSTRACT
OBJECTIVE:
To construct an immunocompetent nipple valve anastomosis (NVA) to exclude faecal reflux and compare it with an end-to-end anastomosis to see if it would prevent recurrent inflammation caused by intraluminal bacterial antigens in Crohn's disease.DESIGN:
Laboratory study.SETTING:
Teaching hospital, Germany. ANIMALS Two groups of six beagle dogs each of which had NVA or end-to-end anastomosis.INTERVENTIONS:
Construction of a NVA by stapling the telescoped nipple, and replacing the ileal mucosa on the valve by colonic mucosa; end-to-end anastomosis. MAIN OUTCOMEMEASURES:
Radiological, bacteriological, angiographic, and morphometric results.RESULTS:
Absolute retrograde pressure-competence and free orthograde permeability of the NVA resulted in significantly lower intestinal bacterial counts compared with the end-to-end anastomosis (p < 0.05). Transposition of colonic mucosa was successful as demonstrated by revascularisation from the ileal nipple and looked normal on morphometry.CONCLUSION:
If NVA were constructed in patients with Crohn's disease, recurrences should be prevented, which would verify the immunopathogenetic hypothesis of new inflammation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações Pós-Operatórias
/
Anastomose Cirúrgica
/
Doença de Crohn
/
Íleo
Tipo de estudo:
Evaluation_studies
Limite:
Animals
Idioma:
En
Revista:
Eur J Surg
Ano de publicação:
2000
Tipo de documento:
Article