Dose-dependent and schedule-dependent effects of interleukin-12 on antigen-specific CD8 responses.
J Interferon Cytokine Res
; 20(6): 589-96, 2000 Jun.
Article
em En
| MEDLINE
| ID: mdl-10888115
ABSTRACT
Interleukin-12 (IL-12) has been shown to play a central role in the innate and acquired immune responses. Its activities include enhancement of natural killer (NK) and cytotoxic T lymphocyte (CTL) activity and promotion of CD4 Th1 cell development. It has also been shown to provide potent activity as a vaccine adjuvant in generating antibody and T cell responses. We have investigated the efficacy of IL-12 protein in promoting CD8 T cell responses when it is used as an adjuvant for immunization. Studies using, as antigen, cDNA from an autologous antigen (P1A) as well as studies of responses to vaccinia virus-delivered self (gp100) and non-self (beta-galactosidase) antigens show that the dose and schedule of IL-12 administration can significantly affect adjuvant activity, leading to enhancement or suppression of antigen-specific responses.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Interleucina-12
/
Linfócitos T CD8-Positivos
Limite:
Animals
Idioma:
En
Revista:
J Interferon Cytokine Res
Ano de publicação:
2000
Tipo de documento:
Article