Azole antifungal agents related to naftifine and butenafine.
Arch Pharm (Weinheim)
; 333(6): 162-6, 2000 Jun.
Article
em En
| MEDLINE
| ID: mdl-10909187
ABSTRACT
The methyl group of naftifine (1) and butenafine (2) was replaced by an azolic nucleus to obtain the new compounds 3-8 which exhibit the characteristics of both allylamine (or benzylamine) and azole antifungals. The title compounds were evaluated in vitro against several pathogenic fungi responsible for human disease. Among these, compounds 5, 6, and 8 were found to inhibit the growth of dermatophytes with a potency comparable to that of naftifine. The synthetic sequence includes the preparation of aminoazole Schiff bases, reduction, and alkylation of the corresponding secondary amines.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzilaminas
/
Alilamina
/
Antifúngicos
/
Naftalenos
Limite:
Humans
Idioma:
En
Revista:
Arch Pharm (Weinheim)
Ano de publicação:
2000
Tipo de documento:
Article