Topographic mapping from the retina to the midbrain is controlled by relative but not absolute levels of EphA receptor signaling.
Cell
; 102(1): 77-88, 2000 Jul 07.
Article
em En
| MEDLINE
| ID: mdl-10929715
ABSTRACT
Topographic maps are a fundamental feature of sensory representations in nervous systems. The formation of one such map, defined by the connection of ganglion cells in the retina to their targets in the superior colliculus of the midbrain, is thought to depend upon an interaction between complementary gradients of retinal EphA receptors and collicular ephrin-A ligands. We have tested this hypothesis by using gene targeting to elevate EphA receptor expression in a subset of mouse ganglion cells, thereby producing two intermingled ganglion cell populations that express distinct EphA receptor gradients. We find that these two populations form separate maps in the colliculus, which can be predicted as a function of the net EphA receptor level that a given ganglion cell expresses relative to its neighbors.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Retina
/
Mapeamento Encefálico
/
Mesencéfalo
/
Transdução de Sinais
/
Receptores Proteína Tirosina Quinases
/
Vias Neurais
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Cell
Ano de publicação:
2000
Tipo de documento:
Article