Increased L-citrulline/L-arginine plasma ratio in severe preeclampsia.
Obstet Gynecol
; 96(3): 395-9, 2000 Sep.
Article
em En
| MEDLINE
| ID: mdl-10960632
ABSTRACT
OBJECTIVE:
To evaluate nitric oxide (NO) production in patients with pregnancy-induced hypertension or preeclampsia and in controls.METHODS:
Four groups of pregnant women were included 17 patients with pregnancy-induced hypertension, ten with mild or moderate preeclampsia, 17 with severe preeclampsia, and 44 normotensive women matched for weeks of gestation at blood sampling with the cases. Plasma levels of L-citrulline and L-arginine were measured by using high-performance liquid chromatography.RESULTS:
The mean plasma levels of L-citrulline and the ratio of L-citrulline to L-arginine, which reflects NO production, were higher in women with severe preeclampsia than in controls, patients with pregnancy-induced hypertension, and patients with mild or moderate preeclampsia.CONCLUSION:
Nitric oxide production is enhanced in severe preeclampsia, possibly as a compensatory phenomenon for the increased synthesis and release of vasoconstrictors and platelet-aggregating agents.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arginina
/
Pré-Eclâmpsia
/
Citrulina
Limite:
Adult
/
Female
/
Humans
/
Newborn
/
Pregnancy
Idioma:
En
Revista:
Obstet Gynecol
Ano de publicação:
2000
Tipo de documento:
Article