Extension of life-span with superoxide dismutase/catalase mimetics.
Science
; 289(5484): 1567-9, 2000 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-10968795
ABSTRACT
We tested the theory that reactive oxygen species cause aging. We augmented the natural antioxidant systems of Caenorhabditis elegans with small synthetic superoxide dismutase/catalase mimetics. Treatment of wild-type worms increased their mean life-span by a mean of 44 percent, and treatment of prematurely aging worms resulted in normalization of their life-span (a 67 percent increase). It appears that oxidative stress is a major determinant of life-span and that it can be counteracted by pharmacological intervention.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Superóxido Dismutase
/
Envelhecimento
/
Catalase
/
Caenorhabditis elegans
/
Antioxidantes
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
2000
Tipo de documento:
Article