Mitochondrial damage in Alzheimer's disease varies with apolipoprotein E genotype.
Ann Neurol
; 48(3): 297-303, 2000 Sep.
Article
em En
| MEDLINE
| ID: mdl-10976635
ABSTRACT
Brain metabolism and the activity of the alpha-ketoglutarate dehydrogenase complex (KGDHC), a mitochondrial enzyme, are diminished in brains from patients with Alzheimer's disease (AD). In 109 subjects, the Clinical Dementia Rating (CDR) score was highly correlated with brain KGDHC activity. In AD patients who carried the epsilon 4 allele of the apolipoprotein E gene (ApoE4), the CDR score correlated better with KGDHC activity than with the densities of neuritic plaques or neuritic tangles. In contrast, in patients without ApoE4, the CDR score correlated significantly better with tangles and plaques than with KGDHC activity. The results suggest that mitochondrial/oxidative damage may be more important for the cognitive dysfunction in AD patients who carry ApoE4 than in those who do not.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apolipoproteínas E
/
Doença de Alzheimer
/
Mitocôndrias
Limite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Ann Neurol
Ano de publicação:
2000
Tipo de documento:
Article