Pharmacological profile of enantiomerically pure chiral muscarinic agonists: desoxymuscarines.
Life Sci
; 67(3): 317-26, 2000 Jun 08.
Article
em En
| MEDLINE
| ID: mdl-10983875
ABSTRACT
The enantiomers desoxymuscarine 6 were tested in vitro on guinea pig tissues, and their muscarinic potency was evaluated at M2 (heart force and rate) and M3 (ileum and bladder) receptor subtypes together with the enantiomers of the parent compound muscarine 1. The eutomers (+)-1 and (+)-6 and distomers (-)-1 and (-)-6 were also assayed in vivo on pithed rat. Affinity, relative efficacy and enantio-selectivity were also determined for the compounds under study at M2 (heart force and rate) and M3 (ileum and bladder), in order to investigate muscarinic receptor heterogeneity. The results of this study have been discussed in comparison with the data previously reported for the structurally related fluoromuscarine (+)-4 and difluoromuscarines (+)-5 and (-)-5.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Agonistas Muscarínicos
/
Muscarina
Limite:
Animals
Idioma:
En
Revista:
Life Sci
Ano de publicação:
2000
Tipo de documento:
Article