Inhibition of T-lymphocyte proliferation by cucurbitacins from Picrorhiza scrophulariaeflora.
J Nat Prod
; 63(9): 1300-2, 2000 Sep.
Article
em En
| MEDLINE
| ID: mdl-11000045
ABSTRACT
Two cucurbitacin aglycons were isolated from the dried rhizomes of Picrorhiza scrophulariaeflora and were identified as 25-acetoxy-2,3, 16,20-tetrahydroxy-9-methyl-19-norlanosta-5,23-dien-22-one (picracin, 1) and 2,3,16,20,25-pentahydroxy-9-methyl-19-norlanosta-5, 23-dien-22-one (deacetylpicracin, 2). Both compounds inhibit mitogen-induced T-lymphocyte proliferation at an IC(50) value of 1 microM.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
/
Triterpenos
/
Linfócitos T
/
Anti-Inflamatórios não Esteroides
Limite:
Humans
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2000
Tipo de documento:
Article