Paraoxonase polymorphisms, pesticide exposure and Parkinson's disease in a Caucasian population.
J Neural Transm (Vienna)
; 107(8-9): 979-83, 2000.
Article
em En
| MEDLINE
| ID: mdl-11041276
ABSTRACT
Parkinson's disease (PD) has been associated with exposure to pesticides and oxidative injury. The involvement of paraoxonase in both pesticide metabolism and lipid peroxidation suggests that it may play a role in the pathogenesis of PD. We examined the frequency of polymorphic alleles of the PON1 and PON2 genes in a sample of caucasian subjects with PD. The frequency distribution of these genotypes did not differ significantly between patients and controls, including those who had reported exposure to pesticides.
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Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Praguicidas
/
Polimorfismo Genético
/
Esterases
Limite:
Female
/
Humans
/
Male
País/Região como assunto:
Oceania
Idioma:
En
Revista:
J Neural Transm (Vienna)
Ano de publicação:
2000
Tipo de documento:
Article