Immunosuppression and resultant viral persistence by specific viral targeting of dendritic cells.
J Exp Med
; 192(9): 1249-60, 2000 Nov 06.
Article
em En
| MEDLINE
| ID: mdl-11067874
ABSTRACT
Among cells of the immune system, CD11c(+) and DEC-205(+) splenic dendritic cells primarily express the cellular receptor (alpha-dystroglycan [alpha-DG]) for lymphocytic choriomeningitis virus (LCMV). By selection, strains and variants of LCMV that bind alpha-DG with high affinity are associated with virus replication in the white pulp, show preferential replication in a majority of CD11c(+) and DEC-205(+) cells, cause immunosuppression, and establish a persistent infection. In contrast, viral strains and variants that bind with low affinity to alpha-DG are associated with viral replication in the red pulp, display minimal replication in CD11c(+) and DEC-205(+) cells, and generate a robust anti-LCMV cytotoxic T lymphocyte response that clears the virus infection. Differences in binding affinities can be mapped to a single amino acid change in the viral glycoprotein 1 ligand that binds to alpha-DG. These findings indicate that receptor-virus interaction on dendritic cells in vivo can be an essential step in the initiation of virus-induced immunosuppression and viral persistence.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
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Antígenos CD
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Terapia de Imunossupressão
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Lectinas Tipo C
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Vírus da Coriomeningite Linfocítica
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
2000
Tipo de documento:
Article