Cell-cycle dysregulation in breast cancer: breast cancer therapies targeting the cell cycle.
Front Biosci
; 5: D938-61, 2000 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-11102317
ABSTRACT
Breast cancer is the most commonly diagnosed cancer in American women. The underlying mechanisms that cause aberrant cell proliferation and tumor growth involve conserved pathways, which include components of the cell cycle machinery. Proto-oncogenes, growth factors, and steroids have been implicated in the pathogenesis of breast cancer. Surgery, local irradiation, and chemotherapy have been the mainstay of treatment for early and advanced stage disease. Potential targets for selective breast cancer therapy are herein reviewed. Improved understanding of the biology of breast cancer has led to more specific "targeted therapies" directed at biological processes that are selectively deregulated in the cancerous cells. Examples include tamoxifen for estrogen receptor positive tumors and imunoneutralizing antibodies such as trastuzumab for Her2/neu overexpressing tumors. Other novel anticancer agents such as paclitaxel, a microtubule binding molecule, and flavopiridol, a cyclin dependent kinase inhibitor, exert their anticancer effects by inhibiting cell cycle progression.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Adenocarcinoma
/
Proteínas de Ciclo Celular
/
Proteínas Supressoras de Tumor
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Front Biosci
Ano de publicação:
2000
Tipo de documento:
Article